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1

SYNTHETIC MELANOTROPIC PEPTIDE INITIATES ERECTIONS IN MEN WITH PSYCHOGENIC ERECTILE DYSFUNCTION: DOUBLE-BLIND, PLACEBO CONTROLLED CROSSOVER STUDY

WESSELLS, HUNTER, FUCIARELLI, KEVIN, HANSEN, JOHN, HADLEY, MAC E., HRUBY, VICTOR J., DORR, ROBERT, LEVINE, NORMAN

Journal:

The Journal of Urology

Year:

1998

Language:

english

File:

PDF, 616 KB

english, 1998

2

The Melanotropic Peptide, [Nle4, d-Phe7]α-MSH, Stimulates Human Melanoma Tyrosinase Activity and Inhibits Cell Proliferation

JINWEN JIANG, SHUBH D. SHARMA, SHELLEY NAKAMURA, JENG-YU LAI, JODY L. FINK, VICTOR J. HRUBY, MAC E. HADLEY

Journal:

Pigment Cell & Melanoma Research

Year:

1995

Language:

english

File:

PDF, 1.08 MB

english, 1995

3

Melanocortin Receptors: Identification and Characterization by Melanotropic Peptide Agonists and Antagonists

MAC E. HADLEY, VICTOR J. HRUBY, JIWEN JIANG, SHUBH D. SHARMA, JODY L. FINK, CARRIE HASKELL-LUEVANO, DAVID L. BENTLEY, FAHAD AL-OBEIDI, TOMI K. SAWYER

Journal:

Pigment Cell & Melanoma Research

Year:

1996

Language:

english

File:

PDF, 2.51 MB

english, 1996

4

Evaluation of Melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study

Robert T. Dorr, Ruskin Lines, Norman Levine, Christine Brooks, Li Xiang, Victor J. Hruby, Mac E. Hadley

Journal:

Year:

1996

Language:

english

File:

PDF, 596 KB

english, 1996

5

Discovery that a melanocortin regulates sexual functions in male and female humans

Journal:

Year:

2005

Language:

english

File:

PDF, 56 KB

english, 2005

6

VII. Topical application of a melanotropic peptide induces systemic follicular melanogenesis

Mac E. Hadley, Sterling H. Wood, Athena M. Lemus-Wilson, Brenda V. Dawson, Norman Levine, Robert T. Dorr, Victor J. Hruby

Journal:

Year:

1987

Language:

english

File:

PDF, 1.54 MB

english, 1987

7

Melanocyte stimulating hormone and melanin concentrating hormone may be structurally and evolutionarily related

Ana Maria de L. Castrucci, Mac E. Hadley, Michal Lebl, Christian Zechel, Victor J. Hruby

Journal:

Regulatory Peptides

Year:

1989

Language:

english

File:

PDF, 473 KB

english, 1989

8

Structure-activity relationships of melatonin and related indoleamines

Christopher B. Heward, Mac E. Hadley

Journal:

Year:

1975

Language:

english

File:

PDF, 500 KB

english, 1975

9

The Control of Bright Colored Pigment Cells of Fishes and Amphibians

BAGNARA, JOSEPH T., HADLEY, MAC E.

Journal:

Integrative and Comparative Biology

Year:

1969

Language:

english

File:

PDF, 6.02 MB

english, 1969

10

Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

Hrubu, Victor J., Lu, Dongsi, Sharma, Shubh D., de L. Castrucci, Ana, Kesterson, Robert A., Al-Obeidi, Fahad A., Hadley, Mac E., Cone, Roger D.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.00 MB

english, 1995

11

Discovery of Prototype Peptidomimetic Agonists at the Human Melanocortin Receptors MC1R and MC4R

Haskell-Luevano, Carrie, Hendrata, Siska, North, Cheryl, Sawyer, Tomi K., Hadley, Mac E., Hruby, Victor J., Dickinson, Chris, Gantz, Ira

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 214 KB

english, 1997

12

Skin Pigmentation and Pharmacokinetics of Melanotan-I in Humans

SYDNEY O. UGWU, JAMES BLANCHARD, ROBERT T. DORR, NORMAN LEVINE, CHRISTINE BROOKS, MAC E. HADLEY, MIKEL AICKIN, VICTOR J. HRUBY

Journal:

Biopharmaceutics & Drug Disposition

Year:

1997

Language:

english

File:

PDF, 152 KB

english, 1997

13

A comparison of HPLC and bioassay methods for plasma melanotan-II (MT-II) determination: Application to a pharmacokinetic study in rats

Sydney O. Ugwu, James Blanchard, Linh D. Nguyen, Mac E. Hadley, Robert T. Dorr

Journal:

Biopharmaceutics & Drug Disposition

Year:

1994

Language:

english

File:

PDF, 395 KB

english, 1994

14

Conformational and dynamic considerations in the design of peptide hormone analogs

Victor J. Hruby, Henry I. Mosberg, Tomi K. Sawyer, James J. Knittel, Todd W. Rockway, James Ormberg, Paul Darman, W. Y. Chan, Mac E. Hadley

Journal:

Year:

1983

Language:

english

File:

PDF, 812 KB

english, 1983

15

D-Isomeric replacements within the 6–9 core sequence of ac-[Nle4]-α-MSH4–11-NH2: A topological model for the solution conformation of α-melanotropin

Elizabeth E. Sugg, Wayne L. Cody, Zalfa Abdel-Malek, Mac E. Hadley, Victor J. Hruby

Journal:

Year:

1986

Language:

english

File:

PDF, 809 KB

english, 1986

16

Melanin concentrating hormone (MCH) effects on teleost (Chrysiptera cyanea) melanophores

Noriko Oshima, Hiroaki Kasukawa, Ryozo Fujii, Brian C. Wilkes, Victor J. Hruby, Ana Maria de L. Castrucci, Mac E. Hadley

Journal:

Journal of Experimental Zoology Part A Ecological Genetics and Physiology

Year:

1985

Language:

english

File:

PDF, 453 KB

english, 1985

17

Synthesis and biological evaluation of the superagonist [Nα-chlorotriazinylaminofluorescein-Ser1, Nle4, D-Phe7]-α-MSH

Dhirendra N. Chaturvedi, Victor J. Hruby, Ana Maria de L. Castrucci, Kristie L. Kreutzfeld, Mac E. Hadley

Journal:

Journal of Pharmaceutical Sciences

Year:

1985

Language:

english

File:

PDF, 523 KB

english, 1985

18

Synthesis and actions of a melanotropin conjugate, Ac-[Nle4, Glu(gamma-4′-hydroxyanilide)5, D-Phe7]α-MSH4–10-NH2, on melanocytes and melanoma cells in vitro

Fahad Al-Obeidi, Marybeth Mulcahy, Valerie S. Pitt, Velma Begay, Mac E. Hadley, Victor J. Hruby

Journal:

Journal of Pharmaceutical Sciences

Year:

1990

Language:

english

File:

PDF, 695 KB

english, 1990

19

Quantitative determination of amino acid racemization in heat-alkali-treated melanotropins: Implications for peptide hormone structure-function studies

Michael H. Engel, Tomi K. Sawyer, Mac E. Hadley, Victor J. Hruby

Journal:

Analytical Biochemistry

Year:

1981

Language:

english

File:

PDF, 713 KB

english, 1981

20

Toxicologic studies of a superpotent α-melanotropin, [Nle4,D-Phe7]α-MSH

Robert T. Dorr, Brenda V. Dawson, Fahad Al-Obeidi, Mac E. Hadley, Norman Levine, Victor J. Hruby

Journal:

Investigational New Drugs

Year:

1988

Language:

english

File:

PDF, 611 KB

english, 1988

21

Design and bioactivities of melanotropic peptide agonists and antagonists: Design based on a conformationally constrained somatostatin template

Victor J. Hruby, Guoxia Han, Mac E. Hadley

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1998

Language:

english

File:

PDF, 274 KB

english, 1998

22

IN VITRO EFFECTS OF STEROID HORMONES ON FROG MELANOPHORES.

Himes, Peggy J., Hadley, Mac E.

Journal:

The Journal of Investigative Dermatology

Year:

1971

File:

PDF, 1.56 MB

1971

23

Stimulation of Follicular Melanogenesis in the Mouse by Topical and Injected Melanotropins.

Levine, Norman, Lemus-Wilson, Athena, Wood, Sterling H., Malek, Zalfa A. Abdel, Al-Obeidi, Fahad, Hruby, Victor J., Hadley, Mac E.

Journal:

The Journal of Investigative Dermatology

Year:

1987

File:

PDF, 2.37 MB

1987

24

Topical Peptides: Percutaneous Absorption of a Vasopressin Derivate, Grass Pollen, and Other Allergens by Iontophoresis in Men.

Remy, Wolfgang, Demmler, Monika, Rakoski, Jurgen, Levine, Norman, Hadley, Mac E., Hruby, Victor I.

Journal:

The Journal of Investigative Dermatology

Year:

1988

File:

PDF, 486 KB

1988

25

In Vitro Transdermal Delivery of a Melanotropic Peptide Through Human Skin.

Dawson, Brenda V., Hadley, Mac E., Levine, Norman, Kreutzfeld, Kristie L., Don, Scott, Eytan, Ted, Hruby, Victor J.

Journal:

The Journal of Investigative Dermatology

Year:

1990

File:

PDF, 1.01 MB

1990

26

Melanotropic peptide receptors: membrane markers of human melanoma cells

Jinwen Jiang, Shubh D. Sharma, Jody L. Fink, Mac E. Hadley, Victor J. Hruby

Journal:

Experimental Dermatology

Year:

1996

Language:

english

File:

PDF, 7.94 MB

english, 1996

27

Exploring the Evolutionary History of Melanin-Concentrating and Melanin-Stimulating Hormone Receptors on Melanophores: Neopterygian (Holostean) and Chondrostean Fishes

WADE C. SHERBROOKE, MAC E. HADLEY

Journal:

Pigment Cell & Melanoma Research

Year:

1988

Language:

english

File:

PDF, 575 KB

english, 1988

28

Calcium-Dependent Irreversible Effect of Ionophore A23187 on Melanophores

Journal:

Pigment Cell & Melanoma Research

Year:

1987

Language:

english

File:

PDF, 420 KB

english, 1987

29

Biomedical Applications of Synthetic Melanotropins

MAC E. HADLEY, BRENDA V. DAWSON

Journal:

Pigment Cell & Melanoma Research

Year:

1988

Language:

english

File:

PDF, 1.07 MB

english, 1988

30

Ionic Requirements for Melanin Concentrating Hormone (MCH) Actions on Teleost Poecilia reticulata Melanophores

MARIA A. VISCONTI, ANA MARIA DE L. CASTRUCCI, E. MAC HADLEY, VICTOR J. HRUBY

Journal:

Pigment Cell & Melanoma Research

Year:

1989

Language:

english

File:

PDF, 482 KB

english, 1989

31

Linear and Cyclic α-Melanotropin [4–10]-Fragment Analogues That Exhibit Superpotency and Residual Activity

MAC E. HADLEY, MOHAMED M. MARWAN, FAHAD AL-OBEIDI, VICTOR J. HRUBY, ANA MARIA DE LAURO CASTRUCCI

Journal:

Pigment Cell & Melanoma Research

Year:

1989

Language:

english

File:

PDF, 540 KB

english, 1989

32

Psoralens Stimulate Mouse Melanocyte and Melanoma Tyrosinase Activity in the Absence of Ultraviolet Light

MOHAMED M. MARWAN, JINWEN JIANG, ANA MARIA DE LAURO CASTRUCCI, MAC E. HADLEY

Journal:

Pigment Cell & Melanoma Research

Year:

1990

Language:

english

File:

PDF, 620 KB

english, 1990

33

Protein-Kinase C Mediates MCH Signal Transduction in Teleost, Synbranchus marmoratus, Melanocytes

MARIA SILVIA ABRÃO, ANA MARIA DE L. CASTRUCCI, MAC E. HADLEY, VICTOR J. HRUBY

Journal:

Pigment Cell & Melanoma Research

Year:

1991

Language:

english

File:

PDF, 505 KB

english, 1991

34

Biological Activities of Melanotropic Peptide Fatty Acid Conjugates

MAC E. HADLEY, FAHAD AL-OBEIDI, VICTOR J. HRUBY, JONATHAN C. WEINRACH, DOUGLAS FREEDBERG, JINWEN JIANG, RACHEL S. STOVER

Journal:

Pigment Cell & Melanoma Research

Year:

1991

Language:

english

File:

PDF, 585 KB

english, 1991

35

Human Epidermal Melanocyte and Keratinocyte Melanocortin Receptors: Visualization by Melanotropic Peptide Conjugated Microspheres (Latex Beads)

JINWEN JIANG, SHUBH D. SHARMA, VICTOR J. HRUBY, DAVID L. BENTLEY, JODY L. FINK, MAC E. HADLEY

Journal:

Pigment Cell & Melanoma Research

Year:

1996

Language:

english

File:

PDF, 1.07 MB

english, 1996

36

The Proopiomelanocortin System

MAC E. HADLEY, CARRIE HASKELL-LUEVANO

Journal:

Annals of the New York Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 951 KB

english, 1999

37

Vertebrate Epidermal Melanin Unit

HADLEY, MAC E., QUEVEDO, WALTER C.

Journal:

Year:

1966

File:

PDF, 454 KB

1966

38

Spontaneous electrical potentials and pituitary hormone (MSH) secretion

DUFF DAVIS, M., HADLEY, MAC E.

Journal:

Year:

1976

File:

PDF, 245 KB

1976

39

Pharmacologic Response of a Controlled-Release PLGA Formulation for the Alpha-Melanocyte Stimulating Hormone Analog, Melanotan-I

Renu Bhardwaj, Mac E. Hadley, Robert T. Dorr, Katarina Dvorakova, Christine Brooks, James Blanchard

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 1.65 MB

english, 2000

40

Design and bioactivities of melanotropic peptide agonists and antagonists: Design based on a conformationally constrained somatostatin template

Victor J. Hruby, Guoxia Han, Mac E. Hadley

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1998

Language:

english

File:

PDF, 108 KB

english, 1998

41

Synthesis and biological activities of fatty acid conjugates of a cyclic lactam .alpha.-melanotropin

Hadley, Mac E., Al-Obeidi, Fahad, Hruby, Victor J., Yaghoubi, Nader, Marwan, Mohamed M.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 784 KB

english, 1992

42

Synthesis and structure-function studies of melanocyte stimulating hormone analogs modified in the 2 and 4(7) positions: comparison of activities on frog skin melanophores and melanoma adenylate cyclase

Hruby, Victor J., Sawyer, Tomi K., Yang, Young C. S., Bregman, Marvin D., Hadley, Mac E., Heward, Christopher B.

Journal:

Journal of Medicinal Chemistry

Year:

1980

Language:

english

File:

PDF, 788 KB

english, 1980

43

Joseph L. LaPointe, 1934-1993

Mac E. Hadley, Howard A. Bern

Journal:

General and Comparative Endocrinology

Year:

1994

File:

PDF, 135 KB

1994

44

Comparative Biological Activities of α-MSH Antagonists in Vertebrate Pigment Cells

Ana Maria de L. Castrucci, Ana Luisa K. Almeida, Fahad A. Al-Obeidi, Mac E. Hadley, Victor J. Hruby, Douglas J. Staples, Tomi K. Sawyer

Journal:

General and Comparative Endocrinology

Year:

1997

Language:

english

File:

PDF, 139 KB

english, 1997

45

Secretion of melanophore-stimulating hormone (MSH) in long-term cultures of pituitary neurointermediate lobes

Samuel Semoff, Bryan B. Fuller, Mac E. Hadley

Journal:

Cell and Tissue Research

Year:

1978

Language:

english

File:

PDF, 1.31 MB

english, 1978

46

Chromatophores and color change in the lizard,Anolis carolinensis

John D. Taylor, Mac E. Hadley

Journal:

Cell and Tissue Research

Year:

1970

Language:

english

File:

PDF, 4.51 MB

english, 1970

47

Long-term and residual melanotropin-stimulated tyrosinase activity in S91 melanoma cells is density dependent

Zalfa A. Abdel Malek, Kristie L. Kreutzfeld, Mac E. Hadley, Marvin D. Bregman, Victor J. Hruby, Frank L. Meyskens

Journal:

In Vitro Cellular & Developmental Biology - Plant

Year:

1986

Language:

english

File:

PDF, 640 KB

english, 1986

48

Cellular mechanisms controlling melanophore stimulating hormone (MSH) release

Mac E. Hadley, Victor J. Hruby, Sr.Annette Bower

Journal:

General and Comparative Endocrinology

Year:

1975

Language:

english

File:

PDF, 1.02 MB

english, 1975

49

Metabolic requirements for melanophore-stimulating hormone (MSH) secretion

Mac E. Hadley, Sr.Annette Bower

Journal:

General and Comparative Endocrinology

Year:

1976

Language:

english

File:

PDF, 1.18 MB

english, 1976

50

Localization of ATPase activity to the glial-like cells of the pars intermedia

Samuel Semoff, Mac E. Hadley

Journal:

General and Comparative Endocrinology

Year:

1978

Language:

english

File:

PDF, 17.80 MB

english, 1978

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